ASIO is all I use in Reaper. And its audio thread priority is maybe influencing this, I'm assuming this is whats making a difference. It still doesnt change the fact that all my other audio devices dont need this work around. This isnt something I've ever had to do before just to stop the audio from being all messed up in any other Windows apps Still, it feels like a step forward in finding where the error is. I'm suspecting the priority for USB audio is off somewhere?