Hopefully you heeded common advice and only "upgraded" (really? Mo-heavy is an "upgrade"? ;-) ) using a cloned drive so that your main audio drive is still intact. (Oops, you said update, which I suppose it is, even if the update may not actually be an UPGRADE?)
I'm on Mavericks with Logic Pro X here, and see no reason to go further with my audio computer. That being said, I'm not sure about the Core Audio having changed in Mo-heavy.
My test machine has all of the various Mac OS flavors from Snow Leopard (still a solid, fast OS) up to Mojave, but I've yet to try Logic Pro X even on High Sierra here.
I'd check on your audio interface to make certain that you are using compatible drivers. That's where many issues have arisen & why only doing an upgrade to a cloned drive seems really prudent.
With Mac OS this is SO very easy, using the on-board Drive Utility to simply "Restore" your main drive to your intended clone. I guess it may help if you're using a dinosaur Mac Pro of the 2009, 2010, 2012 era, with the built in 4 drive bays!
AK